LRP5 gene polymorphism and cortical bone
نویسندگان
چکیده
منابع مشابه
Common Polymorphism in the LRP5 Gene May Increase the Risk of Bone Fracture and Osteoporosis
The low-density lipoprotein receptor-related protein 5 gene (LRP5) was identified to be linked to the variation in bone mineral density and types of bone diseases. The present study was aimed at examining the association of LRP5 rs3736228 C>T gene with bone fracture and osteoporosis by meta-analysis. A systematic electronic search of literature was conducted to identify all published studies in...
متن کاملThe LRP5 high-bone-mass G171V mutation disrupts LRP5 interaction with Mesd.
The mechanism by which the high-bone-mass (HBM) mutation (G171V) of the Wnt coreceptor LRP5 regulates canonical Wnt signaling was investigated. The mutation was previously shown to reduce DKK1-mediated antagonism, suggesting that the first YWTD repeat domain where G171 is located may be responsible for DKK-mediated antagonism. However, we found that the third YWTD repeat, but not the first repe...
متن کاملLRP5 and Wnt signaling: a union made for bone.
THE IDENTIFICATION OF mutations in the human lowdensity lipoprotein (LDL) receptor–related protein 5 (LRP5) gene that give rise to conditions of low bone mass and increased bone mass has brought what just a few years ago were two seemingly unrelated fields crashing together, namely bone biology and Wnt signaling. It is now clear that the Wnt signaling pathway is another key pathway involved in ...
متن کاملFunctional analysis of disease-associated polymorphism LRP5.Q89R
PURPOSE The canonical wingless and Int1 (Wnt) signaling pathway plays key roles in multiple biologic events. The pathway co-receptor, low density lipoprotein receptor-related protein 5 (LRP5), is involved in the pathogenesis of retinal diseases and has been implicated in glaucoma. We studied whether a disease-associated polymorphism LRP5.Q89R, which is located in the second blade of the first β...
متن کاملGender specific LRP5 influences on trabecular bone structure and strength.
A mutation in LRP5 (low-density lipoprotein receptor-related protein 5) has been shown to increase bone mass and density in humans and animals. Transgenic mice expressing the LRP5 mutation (G171V) demonstrate an increase in bone mass as compared to non-transgenic (NTG) littermates. This study evaluated LRP5 gene and gender-related influences on the structural and biomechanical strength properti...
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ژورنال
عنوان ژورنال: Aging Clinical and Experimental Research
سال: 2010
ISSN: 1594-0667,1720-8319
DOI: 10.1007/bf03324935